In prostate cancer cells with high Bcl-2 expression, > 60% of cells die by autophagy, which can be blocked by the autophagy inhibitor 3-methyladenine (MA) or small interfering RNA (siRNA) targeting beclin-1 (the mammalian homolog of yeast Atg6) or Atg5 [16]. Here, BECN1 is linked to Familial prostate cancer.