Compared with oral medicine, insulin therapy involves more links, such as drug selection, treatment plan, injection device, injection technology, SMBG, action based on blood sugar monitoring results, etc. [25, 30] Patients who begin to use insulin should master self-management skills related to insulin therapy through targeted education, understand the risk factors, symptoms and self-rescue measures of hypoglycemia,. This evidence concerns the gene INS and Hypoglycemia.