Among them, a Phase I/II trial is exploring a PI3K inhibitor with nivolumab and ipilimumab (NCT04317105) in PI3K/AKT-mutated solid tumors, while a combination of Nab-rapamycin and nivolumab is under development in advanced sarcoma (NCT03190174) (Table 4). This evidence concerns the gene PIK3CA and sarcoma.