Additional trials evaluating anti-PD-L1 agents plus bevacizumab alone or as part of a larger regimen are actually recruiting in multiple cancer settings including CRC (NCT03869190 and NCT04068610), ovarian cancer (NCT03353831, NCT03806049, NCT03737643 and NCT03596281), HCC (NCT03847428 and NCT03778957) and BC (NCT03395899) and in patients with untreated melanoma brain metastases (NCT03175432) or mucosal melanoma (NCT04091217). Here, CD274 is linked to colorectal carcinoma.