Knowing that (1) Nrf2 is a key initiator of antioxidant response required for the treatment of UC [7,8,9,10]; (2) AG suppresses colitis [17,18,19,20,21,22]; and (3) ginseng and its components (including PA) can induce Nrf2 [24,25,26,27], we hypothesized that Nrf2 is at the crossroads of the protective action of AG, HAG, and PA against colitis. The gene discussed is NFE2L2; the disease is colitis.