Furthermore, recent work by Ren et al. [12] demonstrated that 2-chloro-N6-(3-iodobenzyl)-adenosine-5′-N-methyluronamide (Cl-IB-MECA, Figure 1), a selective A3AR agonist, can inhibit the NF-κB pathway in the colonic epithelia of dextran sulfate sodium (DSS) colitis mice [12]. The gene discussed is ADORA3; the disease is colitis.