TGFB1 and neoplasm: Effector/activated Treg cells (eTreg) inhibit maturation of antigen-specific DCs and also exert non-specific immunosuppressive effects through IL-2 consumption and degradation of ATP to adenosine which impairs T-cell function [76,77] (Figure 2)., Further, Tregs secrete immunosuppressive cytokines IL-10, TGF-β and Il-35 [78] and undergo proliferation in response to tumor-derived factors including TGF-β and IL-10 [79].