Dual annexin V and iodium propidium staining with flow cytometry were used to assess the apoptosis status of breast cancer MCF-7 and MDA-MB-231 cells after 24 h of treatment with a novel series of tested compounds (AuMet-1, PdMet-1, PtMet-1) and cisplatin (Figure 3). This evidence concerns the gene ANXA5 and breast carcinoma.