Our experimental results showed that, among the six hub genes, in particular, PSMB9, ITGAL, and KLRB1, might have the highest potential to be biomarkers of IC/BPS and CD38 and IL7R were also significantly upregulated in IC/BPS patients with Hunner legions. Here, PSMB9 is linked to Bartsocas-Papas syndrome 1.