Adding further support to our conclusion that Nox2-dependent regulation of PPARα signalling is the predominant direction of interaction in this setting, subsequent analysis, focussing on inflammatory pathways as established regulators of LVH [27], identified several PPARα-dependent and independent cytokines as likely mediators of TAC-modified pathways—some of which were strongly predicted to be regulated by upstream Nox2. Here, CYBB is linked to persistent truncus arteriosus.