Interestingly, another study using spontaneously-hypertensive rats reported that fenofibrate protected against cardiac hypertrophy during the initial stages of hypertension (2 months), but with prolonged hypertension (6 months) the cardiac hypertrophic phenotype was aggravated by drug treatment [52], highlighting temporal considerations with regard to PPARα activation. The gene discussed is PPARA; the disease is cardiac hypertrophy.