PPARA and hypertrophic cardiomyopathy: Notably, all three pathways remained unaltered in LV tissue from Nox2−/− mice subjected to TAC, whilst PPARα−/− mice showed significant alterations to both GO response to oxidative stress and KEGG hypertrophic cardiomyopathy pathway (Figure 6B,C), consistent with the observed worsened LVH phenotype.