High levels of these molecules, including interleukin (IL) 6, IL–2, IL–2 receptor (IL–2R), IL–10, tumor necrosis factor alpha (TNF–α) and interferon gamma (IFN–γ), have been described in patients with severe and refractory COVID–19 [44,45,63,115]. The gene discussed is IFNG; the disease is COVID-19.