Although macrophages (CD68+ cells) were the first immune cell type realized to infiltrate adipose tissue (AT) in obesity and to associate with obesity-related metabolic dysfunction [1], the current view in the field engages virtually all immune cell types in obesity-associated AT inflammation, including T and B lymphocytes (and their sub-classes), dendritic cells, neutrophils, and natural killer (NK) cells [2]. The gene discussed is CD68; the disease is obesity disorder.