CMA1 and obesity due to melanocortin 4 receptor deficiency: For this analysis, we found a yet stronger association when using VAT-CMA1 expression only (Figure 5A,B): People with obesity and high VAT-CMA1 expression achieved 1.74-fold greater weight reduction compared to obese people with low VAT-CMA1 expression 6 months post-surgery (p = 0.016).