For instance, HOTAIR is a miR-148a sponge that regulates Slug to promote EMT expression in esophageal cancer [24], lincRNA-ROR induces EMT through ZEB regulation by inhibition of miR-205 in breast cancer [25] and H19 operates as a sponge for let-7 to increase HMGA-2 mediated EMT in pancreatic cancer [26]. This evidence concerns the gene HOTAIR and familial pancreatic carcinoma.