BRD4 and nut midline carcinoma: We found that, compared to unphosphorylated BRD4 in noncancerous cells, hyperphosphorylated BRD4 observed in NMC binds chromatin with much higher affinity [44], suggesting a mechanism by which BRD4 hyperphosphorylation stimulates abnormal induction of target oncogenes to drive highly aggressive NMC oncogenesis [43,44,45,46].