SOD1 and psoriasis: Studies conducted on rats receiving methotrexate, a prooxidative drug used in the treatment of psoriasis, showed an improvement in terms of antioxidative parameters (GPX, SOD, MDA) and the serum lipid profile (TC, HDL-chol, LDL-chol) after the oral administration of 500 mg per kg of pomegranate in the form of a methanol extract from seeds or peels [144,145].