FMR1 and fragile X-associated tremor/ataxia syndrome: Figure 3 shows the proteins involved in FMR1 RNA-induced sequestration. Ubiquitin positive inclusions are the hallmark of FXTAS [75,129,130]; they contain FMR1 mRNA but lack FMRP [131,132]. Inclusions are an aggregate of protein, composed of a heterogeneous assortment of many peptides. The DNA damage response proteins found in the inclusions form in response to oxidative stress leading to neurodegeneration [132].