FXTAS was first described in 2001 by Hagerman and colleagues [11] when they reported five elderly males who were carriers of the PM and presented with a progressive intention tremor, difficulty with ambulation, deficits in executive function and brain atrophy in association with elevated FMR1 messenger RNA (mRNA) levels. This evidence concerns the gene FMR1 and fragile X-associated tremor/ataxia syndrome.