SLC29A3 and cancer: On the other hand, lysosomes might improve efficacy of lipid nanodrugs that overcome cancer cell resistance, nanoparticles enter into the cancer cells by endocytosis and the drug is released from nanoparticles by acidic proteases in lysosomes, from which the drug can be transported into the cytoplasm by active transport, e.g., by hENT3 [76].