Similar NOTCH1 and NOTCH2 mutations have been seen in multiple B-cell malignancies including chronic lymphocytic leukaemia (CLL), mantle cell lymphoma (MCL), Hodgkin’s and Burkitt’s lymphomas, further supporting its role in these haematological malignancies [50,51,52]. The gene discussed is NOTCH1; the disease is B-cell chronic lymphocytic leukemia.