A meta-analysis of 13 studies, including 3401 patients, reported a significant association between Notch 1 expression and colorectal cancer samples compared to noncancerous normal tissues, and clinical parameters were indicative of colorectal cancer invasion and metastasis (e.g., lymph node metastasis and depth of tumour infiltration in the surrounding tissue) [85]. The gene discussed is NOTCH1; the disease is colorectal cancer.