In a clinical cohort of breast cancer samples, Notch 1 and Notch 2 were shown to have a reciprocal association with prognosis; high Notch 1 was associated with poor prognosis, while high Notch 2 was associated with better prognosis, suggesting a protective role of Notch 2 [77]. The gene discussed is NOTCH1; the disease is breast carcinoma.