Interestingly, other clinical trials of the anti-Notch 1 receptor antagonist such as brontictuzumab and the GSI LY3039478 also demonstrated antitumour activity or disease stabilisation in small numbers of ACC patients, further supporting the rationale for Notch-mutant ACC patients as likely candidates responsive to Notch therapy. This evidence concerns the gene NOTCH1 and adrenal cortex carcinoma.