SP4 and hepatocellular carcinoma: Recently, new formulations have been developed by combining the SP94 with drug delivery systems, including mesoporous silica nanoparticle-supported lipid bilayers, virus like particles (VLPs) such as the bacteriophage MS2 as well as the 99mTc/188ReHYNIC-SP94, that is a probe targeting SP4 to HCC cells for imaging and therapy [153,154,155].