RIGI and atherosclerosis: We found that DEPs were mainly involved in 6 signaling pathways, including extracellular matrix (ECM)-receptor interaction (P14287, Q8HZJ6, K7GNF5), fluid shear stress and atherosclerosis (A0A287AD21, P61958, A7WLH8, Q8HZJ6, K7GNF5), RNA transport (A0A286ZWZ7, A0A287AD21, P61958, A7WLH8, A0A287BF68), thyroid hormone synthesis (P50390 and F1RZR0), retinoic acid–inducible gene I (RIG-I)-like receptor signaling pathway (A0A287AB58, F1S8C6), and cell adhesion molecules signaling pathway (Q8HZJ6 and K7GNF5) (Figure 3B, Table S5).