TKT and central nervous system cancer: In this study, we designed and constructed a lentivirus (pFu-FGT) with three reporter genes, green fluorescent protein (GFP), luciferase (luc), and herpes simplex virus type 1-thymidine kinase (HSV1-tk), transfected it into the glioma cell line F98, and evaluated the antitumor capacities of curcumin alone, radiation alone, and curcumin plus radiation at cell and animal levels with a multimodality molecular imaging methodology.