ESRP1 and breast carcinoma: Fici and coworkers, analyzing EMT-related splicing factors ESRP1/ESRP2/RBFOX2, provided rationale to use the ESRP1/RBFOX2 ratio as a prognostic biomarker for early prediction of metastasis in breast cancer, and further suggested this ratio could also be evaluated in CTCs [365]