CETP and chronic kidney disease: The change in the CETP activity was described using a turnover model:(4)dCETPactivitydt=Kin,base×(1+Placebo)−Kout×(1+Drug)where Kin, base is the zero-order constant for the increase of CETP activity at baseline, placebo is the placebo response to CETP activity, Kout is the first-order rate constant for the decrease in CETP activity, and Drug is the effect of CKD-519 on CETP activity.