HPRT1 and colorectal cancer: For example, reverse virtual docking was used to predict the targets of apple polyphenols in preventing colorectal cancer, and the main targets were guanosine 5′-monophosphate oxidoreductase (GMP reductase), guanosine triphosphatase (GTPase), and hypoxanthine-guanine phosphoribosyltransferase (HGPRT) [30].