To the best of our knowledge, this is the first study reporting significant and distinct alterations of plasma concentrations from three different classes of proinflammatory mediators that are essential for vascular development, integrity and remodeling (i.e., angiopoietins, VEGFs, and secretory phospholipase A2) in patients with two forms of HF (i.e., ischemic and non-ischemic). Here, PLA2G2D is linked to hydrops fetalis.