LCN2 and hepatocellular carcinoma: The idea that high levels of LCN2 inhibit tumor growth is supported by the study conducted by Lee et al., who overexpressed LCN2 in HCC cells and observed an inactivation of the c-Jun N-terminal kinase (JNK) and phosphatidylinositol 3’-kinase (PI3K)/Akt signaling pathway [84].