Finally, a study of breast cancer showed that overexpression of LCN2 in 4T1-H-Ras-transformed cells (4T1-R) reverted the mesenchymal phenotype of the 4T1-R cells to a more epithelial phenotype by increasing E-cadherin, reducing vimentin, and suppressing cell invasion [56]. This evidence concerns the gene LCN2 and breast cancer.