Lamina propria of CVID cases showed an enrichment of Foxp3+, GATA3+, CD4+ and CD8+ lymphocytes (p < 0.001; p = 0.002; p < 0.001; p = 0.001) and higher expression of PD-L1+ immune cells (p = 0.011). Here, CD4 is linked to common variable immunodeficiency.