SMPDL3B and posterior cortical atrophy: In the tissue scan cohort, multiple comparison showed significant overexpression of SMPDL3B in both locally confined (T1/2: 5.42×, p = 0.001) and locally advanced (T3/4: 8.94×, p < 0.001) PCa and in different Gleason groups (≤ 6: 7.01×, p = 0.002; 7: 6.00×, p < 0.001; ≥ 8: 7.14×, p = 0.004) compared to BPH.