To further investigate whether ABCA1 deficit induces disturbance in oligodendrogenesis after stroke, we measured the number of newly born OPCs and newly matured OLs in the ischemic brain, and we found a reduced number of newly born OPCs and OLs in the IBZ of cortex and CC in ABCA1-B/-B stroke mice compared with ABCA1fl/fl stroke mice, which indicates that ABCA1-B/-B reduces oligodendrogenesis after stroke. Here, ABCA1 is linked to stroke disorder.