However, compared with ABCA1-B/-B vehicle stroke mice, the administration of HDL3 or ApoE2 into the ischemic brain significantly increased the numbers of APC+-OLs/PDGFRα+-OPCs and APC+/BrdU+-OLs/PDGFRα+/BrdU+-OPCs in the IBZ of ischemic brain in ABCA1-B/-B mice 21 days after stroke (Figure 4, p < 0.05, n = 9/group). This evidence concerns the gene APC and stroke disorder.