In the rare RCC category, collecting duct carcinoma (CDC) harbors mutations in NF2, SETD2, SMARCB1, FH, and CDKN2A genes [79] while renal medullary carcinoma is distinctively characterized by loss of SMARCB1/INI1 tumor suppressor protein [48]. This evidence concerns the gene SMARCB1 and renal cell carcinoma.