Microphthalmia-associated transcription (MiT) family translocation RCC is defined by transcription factor binding to IGHM enhancer 3 (TFE3) (Xp11.2) and transcription factor EB (TFEB) (t(6;11)) translocation and succinate dehydrogenase-deficient RCC [46,47]. The gene discussed is TFEB; the disease is renal cell carcinoma.