The decrease of both Cnr1 and Nape-pld in the PP groups could indicate a decrease in AEA, that would explain the increase in anxiety in these animals, since the anxiolytic role of this endocannabinoid has been demonstrated, and the pharmacological augmentation of central endogenous cannabinoid (eCB) signaling being a promising treatment for anxiety disorders [44]. This evidence concerns the gene CNR1 and anxiety disorder.