Furthermore, increased anxiety in PP animals is associated with specific changes in the prefrontal cortex’s (PFC) mRNA expression of ionotropic and metabotropic glutamate receptors, such as Grin1, Gria1 and Grm5, and endocannabinoid signaling elements, such as the Cnr1 receptor or the endocannabinoid-synthesis/degrading enzymes Diacylglycerol lipase-beta (Daglβ) and N-acyl phosphatidylethanolamine phospholipase D (Nape-pld). The gene discussed is GRM5; the disease is Anxiety.