Similarly, TRPM3 has been found upregulated in clear cell renal cell carcinoma cell lines 786-O or A498 and its knockdown or inhibition suppressed growth of tumours generated from renal carcinoma cells in orthotopic xenograft mouse models, suggesting an oncogenic role for TRPM3 in renal cancer [183]. Here, TRPM3 is linked to clear cell renal carcinoma.