MAPT and early-onset autosomal dominant Alzheimer disease: The aggregation of hyperphosphorylated tau that leads to the formation of neurofibrillary tangles has been implicated in a variety of tauopathies, including Alzheimer’s disease (AD), frontotemporal dementia, Pick disease, argyrophilic grain disease, progressive supranuclear palsy, and corticobasal degeneration [3].