For example, thanks to iPSC-based screening, it was possible to identify a new application for ezogabine, an anti-epileptic drug, in amyotrophic lateral sclerosis (ALS) treatment [85] and to highlight the beneficial effects of MAP4K4 gene silencing on an iPSCs-CMs model of ischemic injury [86]. This evidence concerns the gene MAP4K4 and amyotrophic lateral sclerosis.