CRH and Anxiety: A second aspect deserving discussion is the fact that ACE2 overexpression in corticotropin-releasing-hormone (CRH)-producing neurons in the hypothalamic paraventricular nucleus alters the processing of psychogenic stress in mice, decreasing the CRH content in the hypothalamus and corticosterone plasma levels (i.e., less HPA axis activation), as well as anxiety-like behaviors (102).