Interleukin 6 (IL6) is a pro-inflammatory cytokine that plays a pivotal role in the development, progression, and severity of CRS as well as its complications, including disseminated intravascular coagulopathy (DIC) and multiorgan failure (The National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS), 2006; Teachey et al., 2013; Garcia Borrega et al., 2019; Khadka et al., 2019). This evidence concerns the gene IL6 and congenital rubella syndrome.