TMEM67 and Hepatic fibrosis: The less severe NPHP phenotype in our patients was caused by the fact that all children carried the allele p.Cys615Arg (three in homozygous and one in heterozygous state with another TMEM67 variant), which was already described in 2009 by Otto et al. [33] as hypomorphic allele associated with phenotype of NPHP with hepatic fibrosis and no brain anomaly.