CXCL10 and infection: Interestingly, suppression of H. hammondi-induced CXCL10 production also occurred when THP-1 cells were first exposed to T. gondii/THP-1 conditioned media (harvested 4 h post-infection; Fig 7B), suggesting that T. gondii-mediated suppression is due, at least in part, to parasite- and/or host cell-derived soluble mediators released during infection.