Interestingly, we observed that the number of pDCs in the spleen and lymph node decreased after infection and treatment with anti-CXCR3 antibody when we compared to the isotype control group (Fig 7A and 7B); also, pDCs expressed CXCR3 receptor on the surface after infection (Fig 7C and 7D). This evidence concerns the gene CXCR3 and infection.