Whether similar release could also occur in pyroptotic endothelial cells has not been addressed, but appears plausible since: 1-pyroptosis has also been described in endothelial cells; 2-patients with COVID-19 have elevated levels of lactate dehydrogenase, a marker of pyroptosis [56]; 3-inflammasome activation, which is also triggered by STING, can lead to pyroptosis and TF release following other innate over-immune responses associated with tissue damages [57]. This evidence concerns the gene TF and COVID-19.