Most recurrent translocations such as t(4;14) involving IGH‐MMSET/FGFR3(OMIM 146910)/(OMIM 134934),t(6;14) involving IGH‐CCND3(OMIM 146910)/(OMIM 123834), t(11;14) involving IGH‐CCND1, t(14;16) involving IGH‐MAF(OMIM 146910)/(OMIM 177075), and t(14;20) involving IGH‐MAFB(OMIM 146910)/(OMIM 608968) are regarded as primary cytogenetic events that initiate tumor development. The gene discussed is NSD2; the disease is neoplasm.