It is also possible that within the context of cancer, mutations to tumor suppressor and/or oncogenes may result in dysregulation of ASCL1 and the other transcription factors to be aberrantly coexpressed in neural progenitors or OPCs, thereby suppressing their differentiation and maintaining these cells in a constant state of proliferation, eventually leading to glioma formation. This evidence concerns the gene ASCL1 and glioma.