Despite these findings, RNA‐seq from a Nf1;Tp53CKO mouse model of glioma where the tumors also lack ASCL1 revealed that although some Notch related genes (Dll3, Hes5, Hes6) were decreased, expression of many of the Wnt related genes seemed unaffected by the loss of ASCL1. Here, ASCL1 is linked to central nervous system cancer.