NF1 and TP53 are two of the most highly mutated genes in human GBM (Brennan et al., 2013; Verhaak et al., 2010), and Cre‐recombinase deletion of these two tumor suppressor genes (Nf1;Tp53CKO) in neural progenitors or glial precursor cells have previously been shown to be fully penetrant in producing glioma tumors in the brains of mice (Alcantara Llaguno et al., 2009; Alcantara Llaguno et al., 2015; Zhu et al., 2005). The gene discussed is TP53; the disease is glioblastoma.