Similar to the findings reported here, deletion of Nf1, Tp53, along with or without Pten at adult stages, produces glioma tumors in the brains of mice using multiple neural stem/progenitor cell type specific Cre drivers (Alcantara Llaguno et al., 2009; Alcantara Llaguno et al., 2015; Zhu et al., 2005). Here, PTEN is linked to central nervous system cancer.