Despite these findings, RNA‐seq from a Nf1;Tp53CKO mouse model of glioma where the tumors also lack ASCL1 revealed that although some Notch related genes (Dll3, Hes5, Hes6) were decreased, expression of many of the Wnt related genes seemed unaffected by the loss of ASCL1. The gene discussed is HES5; the disease is central nervous system cancer.