Other studies also reported that Ang II involved in the development of various cardiovascular diseases by disrupting microvessel permeability,22 inhibited the protein expression of ZO‐1 in vascular endothelial cells by down‐regulating vascular endothelial (VE)‐cadherin, and then destroying the tight junctions between endothelial cells.23 This evidence concerns the gene CDH17 and cardiovascular disorder.