P2RY12 and multiple sclerosis: To test this, we induced recombination in P2ry12-CreER; Rosa26Ai14 mice and then studied these mice in two separate injury models: unilateral MCAO (middle cerebral artery occlusion), a model of ischemic stroke, and EAE (experimental autoimmune encephalomyelitis), a model of neuro-inflammatory injury similar to human multiple sclerosis.