A previous study in a Finnish population demonstrated a trend toward increased stroke risk across galectin‐3 quartiles that was not significant after adjustment for traditional risk factors.11 In ARIC, the association between galectin‐3 and ischemic stroke remained after adjustments for traditional risk factors, eGFR, NT‐proBNP, and hs‐TnT. This evidence concerns the gene NPPB and Stroke.