In this study, we identified a mutation within ZP3, c.400G>A p.A134T in a sterile female patient, and the mutation was further confirmed in her family characterized by a dominant inheritance pattern; further, we investigated a novel heritable mutation in ZP1 (NM_207341:c.326G>A) that was found in a primary infertile female patient from whom 5 degenerated oocytes and three mature oocytes with no ZP were retrieved in an ICSI attempt. Here, ZP1 is linked to Infertility.