In order to investigate whether the GH insensitivity is due to changes in GHR receptor biology, as occurs in Laron syndrome (due to GHR mutation) or during fasting (downregulation of GHR), we quantified hepatic GHR, but its levels were unchanged (Laron, 2015; Straus & Takemoto, 1990). This evidence concerns the gene GHR and Laron syndrome.