We also observed a negative correlation between the levels of NSD2 and CDKN1A/p21 in cancer cell lines (Figure S5b,c), whereas most of the upregulated genes in NSD2‐KD cells showed no negative correlation with NSD2. We further found a positive correlation between Nsd2 and cell cycle‐associated genes in mouse normal tissues by qRT‐PCR (Figure 6b). The gene discussed is CDKN1A; the disease is cancer.