Given that the expression levels of NSD2 are dynamically regulated during the cell cycle (Evans et al., 2016) and that NSD2 is overexpressed in various types of cancer cells (Vougiouklakis et al., 2015), the role of NSD2 might vary in cell cycle‐ and dose‐dependent manners as well as in a genomic locus‐specific manner. This evidence concerns the gene NSD2 and cancer.