In conclusion, mechanisms of EBNA1 favor accumulation of Treg in NPC through: (a) upregulated TGF‐β1 converted naïve T cell into Treg; (b) upregulated CCL20 increased Tregs migration; and (c) polarized‐M2 macrophage converted naïve T cell into Tregs. Here, TGFB1 is linked to nasopharyngeal carcinoma.