Besides its eminent vasoactive role, peptidergic psychoactive implications of CGRP have been repeatedly described in humans and, translationally, in various animal models, with a crucial involvement in multifaceted neurobehavioral processes [40] such as depression [41–47], anxiety [48], learning and memory [49], possibly in dementia [50], in the pathophysiology of inflammatory and neuropathic pain [51–53], and, by unalterable cerebral vasodilation, in migraine [54–56]. The gene discussed is CALCA; the disease is major depressive disorder.