CALCA and major depressive disorder: In accordance with the psycho-behavioral literature, our study postulates a detrimental effect of CSF CGRP on psychological and physical health: Increased CSF AUC CGRP levels were significantly positively correlated to depression, anxiety, compulsive-obsessive syndrome, and the supplementary ISR items (which imply a variety of concomitant syndromes including problems with activities of daily living, sleep, concentration, flash backs, obliviousness, feelings of displacement and alienation, suicidality, appetite, and non-organic sexual dysfunction).