In line with preclinical data and the psychiatric literature, the present data suggests that, after sSAH, increased CSF CGRP concentrations significantly adversely affect short-term psychological and physical health with respect to depression, anxiety, somatoform syndrome, compulsive-obsessive syndrome, the supplementary ISR items, general health perceptions, and the SF-36 physical component summary score. This evidence concerns the gene CALCA and major depressive disorder.