Therefore, to model the complex IV deficient DRG neurons that are observed in MS, we developed a neuron-specific inducible mitochondrial mutant by knocking out complex IV subunit 10 (COX10 or protohaem IX farnesyltransferase) in DRG neurons (COX10Adv mutant mice, Fig. 5) [13, 31]. This evidence concerns the gene COX10 and myeloid sarcoma.